Dimitris avramopoulos biography of michael jackson
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Published in final edited form as: Circulation. Nov 24;(5)– doi: /CIRCULATIONAHA
Abstract
Background:
Plasma proteins are critical mediators of cardiovascular processes and are the targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma proteome have been limited by a focus on individuals of European descent and leveraged genotyping arrays and imputation. Here we describe whole genome sequence analysis of the plasma proteome in individuals with greater African ancestry, increasing our power to identify novel genetic determinants.
Methods:
Proteomic profiling of 1, proteins was performed in Black adults from the Jackson Heart Study using aptamer-based proteomics (SomaScan®). Whole genome sequencing association analysis was ascertained for all variants with minor allele count ≥ 5. Results were validated using an alternative, antibody-based, proteomic platform (Olink®) as well as replicated in
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Background
Asthma is a common respiratory disorder with a highly heterogeneous natur that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung function in individuals with a diagnosis of asthma.Methods
WGS data were generated for 1, individuals from trios and extended pedigrees participating in the family-based Genetic Epidemiology of Asthma in Costa Rica study. Asthma affection status was defined through a physician's diagnosis of asthma, and most participants with asthma also had airway hyperresponsiveness (AHR) to methacholine. Family-based association tests for single variants were performed to assess the associations with lung function phenotypes.Results
A genome-wide significant association was identified between baseline FEV1/FVC ratio and a single-nucleotide polymorphism in the top hit cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) (rs; P = &n•
Helena Paparizou
Greek singer (born )
Helena Paparizou (Swedish:[hɛˈlêːnapapaˈrɪ̌tːsʊ,-ˈrǐːsʊ]; Greek: Έλενα Παπαρίζου, romanized:&#;Élena Paparízou, pronounced[ˈelenapapaˈrizu], born 31 January ), is a Greek-Swedish singer, songwriter and television personality. Born and raised in Sweden to Greek parents, she launched her singing career in Sweden in as a member of the laïko (Greek folk music) and Eurodance duo Antique with friend Nikos Panagiotidis. The group released five studio albums between and , and represented Greece in the Eurovision Song Contest
Antique disbanded in , and Paparizou signed a solo recording contract with Sony Music. Her debut solo single "Anapandites Kliseis" preceding the album Protereotita (); her style had an emphasis on laïko, pop, and dance sounds. In , she represented Greece in the Eurovision Song Contest with the song "My Number One", which won the contest for Greece for the first time. Paparizou attempted a career beyond